The human flora...what are they good for?
- Randydeluxe
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Re: The human flora...what are they good for?
It's interesting to think that you're harboring many bacteria that you yourself cannot tolerate. For example, there are bacteria that you can live in your colon every day of your life without worry. But take those same bacteria and try to harbor them in your sinuses, or your kidneys, and bad things happen.
Re: The human flora...what are they good for?
So you're saying I should scrap my bacteria self-transportable nano-travel-ships endeavor? I was really out there to improve their life quality, but if that's the outcome...Randydeluxe wrote:It's interesting to think that you're harboring many bacteria that you yourself cannot tolerate. For example, there are bacteria that you can live in your colon every day of your life without worry. But take those same bacteria and try to harbor them in your sinuses, or your kidneys, and bad things happen.
- GenesForLife
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Re: The human flora...what are they good for?
Microbes can live fine without us helping them, Dory, they can even withstand high doses of gamma radiation, UV radiation, acidic conditions, dessication and so on, and in Deinococcus radiodurans combined most of those things into one unicellular package.
http://www.plosone.org/article/info%3Ad ... ne.0012570For Deinococcus radiodurans and other bacteria which are extremely resistant to ionizing radiation, ultraviolet radiation, and desiccation, a mechanistic link exists between resistance, manganese accumulation, and protein protection. We show that ultrafiltered, protein-free preparations of D. radiodurans cell extracts prevent protein oxidation at massive doses of ionizing radiation. In contrast, ultrafiltrates from ionizing radiation-sensitive bacteria were not protective. The D. radiodurans ultrafiltrate was enriched in Mn, phosphate, nucleosides and bases, and peptides. When reconstituted in vitro at concentrations approximating those in the D. radiodurans cytosol, peptides interacted synergistically with Mn2+ and orthophosphate, and preserved the activity of large, multimeric enzymes exposed to 50,000 Gy, conditions which obliterated DNA. When applied ex vivo, the D. radiodurans ultrafiltrate protected Escherichia coli cells and human Jurkat T cells from extreme cellular insults caused by ionizing radiation. By establishing that Mn2+-metabolite complexes of D. radiodurans specifically protect proteins against indirect damage caused by gamma-rays delivered in vast doses, our findings provide the basis for a new approach to radioprotection and insight into how surplus Mn budgets in cells combat reactive oxygen
Re: The human flora...what are they good for?
I bet they're immune to AIDS, too.GenesForLife wrote:Microbes can live fine without us helping them, Dory, they can even withstand high doses of gamma radiation, UV radiation, acidic conditions, dessication and so on, and in Deinococcus radiodurans combined most of those things into one unicellular package.
http://www.plosone.org/article/info%3Ad ... ne.0012570For Deinococcus radiodurans and other bacteria which are extremely resistant to ionizing radiation, ultraviolet radiation, and desiccation, a mechanistic link exists between resistance, manganese accumulation, and protein protection. We show that ultrafiltered, protein-free preparations of D. radiodurans cell extracts prevent protein oxidation at massive doses of ionizing radiation. In contrast, ultrafiltrates from ionizing radiation-sensitive bacteria were not protective. The D. radiodurans ultrafiltrate was enriched in Mn, phosphate, nucleosides and bases, and peptides. When reconstituted in vitro at concentrations approximating those in the D. radiodurans cytosol, peptides interacted synergistically with Mn2+ and orthophosphate, and preserved the activity of large, multimeric enzymes exposed to 50,000 Gy, conditions which obliterated DNA. When applied ex vivo, the D. radiodurans ultrafiltrate protected Escherichia coli cells and human Jurkat T cells from extreme cellular insults caused by ionizing radiation. By establishing that Mn2+-metabolite complexes of D. radiodurans specifically protect proteins against indirect damage caused by gamma-rays delivered in vast doses, our findings provide the basis for a new approach to radioprotection and insight into how surplus Mn budgets in cells combat reactive oxygen
- GenesForLife
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Re: The human flora...what are they good for?
haha , of course , because the genetics of HIV doom it to replicating only in human CD4+ T Lymphocytes / suitably modified animal models 

Re: The human flora...what are they good for?
*smacks forehead*GenesForLife wrote:haha , of course , because the genetics of HIV doom it to replicating only in human CD4+ T Lymphocytes / suitably modified animal models
While we're at all, can you tell me why don't bacteria ever get sore muscles?....
- GenesForLife
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Re: The human flora...what are they good for?
They don't have anyDory wrote:*smacks forehead*GenesForLife wrote:haha , of course , because the genetics of HIV doom it to replicating only in human CD4+ T Lymphocytes / suitably modified animal models
While we're at all, can you tell me why don't bacteria ever get sore muscles?....

Just playing the Captain Obvious card, Dory

Re: The human flora...what are they good for?

Oh...I lost the mutual plot somewhere... come here for a sloppy one Bertie Wooster!

- GenesForLife
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Re: The human flora...what are they good for?
I blame Elle for that name...
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Re: The human flora...what are they good for?
The ones that benefit us (if only in Clinton's sense) may not be targetted by our immune system, so it may still be a case of I'll scratch your back if you scratch mine...Feck wrote:They are not there TO do any thing they happen to have found a niche they are exploiting it they fact that some of then benefit us is just handy
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Re: The human flora...what are they good for?
Blame? It's catchy and neat, and much better than Genes For Life or whatever your unpronounceable superfluously long Hindu name is.GenesForLife wrote:I blame Elle for that name...

- GenesForLife
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Re: The human flora...what are they good for?
It is a Sanskrit name, not a Hindu name... Ankur means sapling in Sanskrit , the long bits come from my father's name and my family name, which mean "Sun" and "Emperor of emperors"Dory wrote:Blame? It's catchy and neat, and much better than Genes For Life or whatever your unpronounceable superfluously long Hindu name is.GenesForLife wrote:I blame Elle for that name...
respectively in Sanskrit.
Re: The human flora...what are they good for?
*sighs* If you only had a Hindu accent and knew me IRL, you wouldn't know rest from my mockings.....
- GenesForLife
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Re: The human flora...what are they good for?
There are several different Indian accents, nothing like a Hindu accent again... someone down south, in Kerala for instance, will speak very differently from a Bengali (ask Natselrox)Dory wrote:*sighs* If you only had a Hindu accent and knew me IRL, you wouldn't know rest from my mockings.....
Punjabis speak differently, central Indians speak differently.
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