Home brewed hard drugs

[Blind groper]

http://www.sciencedirect.com/science/ar ... 7915303900

Within a few years, genetically modified yeast will be created, that makes morphine. Once created, it is hard to see that yeast remaining locked up in labs, especially now that simple genetic modification is leaving the lab, and becoming possible at home.

With just a pinch of the yeast, it would then be ridiculously easy to make hard drugs at home. Just buy some home brew nutrient mix, and add the yeast. Within a few days, you will have a brew that can get you high. Just take a few sips.

To make more, just mix some fresh brew and add a bit of the old brew, which will still have yeast in it.

It would even be possible to turn the morphine into heroin. The chemistry is simple, and the instructions are on the internet.

The big question is whether this is going to be a good or bad thing. Drug pushers will be out of a job, but will probably simply turn to some other kind of crime. Users will get ridiculously cheap drug. Will non users be tempted? Or will they avoid the drug as they do now?

[JimC]

Interesting post, BG. I suspect that the effect will be mixed, but perhaps, if it eventuates, the good (reduction in dangerous criminal activity) will outweigh the bad (a potential increase in stoned out zombies)

[piscator]

How to make heroin: https://www.erowid.org/archive/rhodium/ ... inmfg.html

[rainbow]

Alcohol is a hard drug.

Withdrawal is more severe than heroin, there are more addicts, and it kills more people.

[Svartalf]

I still like my booze

[rainbow]

I still like my booze

...so do I.

[Hermit]

How to make heroin: https://www.erowid.org/archive/rhodium/ ... inmfg.html

Not clicking on this. I don't want the Australian Federal Police inviting me for an interview, turning my home upside down and startling the cat.

[rainbow]

You said "cat". Clearly then you've been cooking up pseudoephedrine with old lithium batteries.

Gotcha!

[piscator]

How to make heroin: https://www.erowid.org/archive/rhodium/ ... inmfg.html

Not clicking on this. I don't want the Australian Federal Police inviting me for an interview, turning my home upside down and startling the cat.

The fun part, for those presently cowering under the yoke of an oppressive nannystate:

3.) Conversion of morphine to heroin base.

The key chemical used in the acetylation of morphine to form heroin is acetic anhydride, a colorless, highly combustible liquid with a strong pickle-like odor. Though internationally controlled as a heroin precursor, acetic anhydride also used to synthesize aspirin and chemicals for leather tanning and photography. Morphine hydrochloride or morphine base is mixed with acetic anhydride at about three-times the mass of the former in a stainless steel or enamel pot. The pot lid is tied or clamped on with a damp towel for a gasket (a makeshift reflux apparatus), and the mixture is heated at 85 degrees Celsius (185 degrees F), avoiding boiling. The cooking proceeds for about 5 hours until all the morphine has dissolved. The pot is opened, and the mixture -- now a solution of water, acetic acid, and diacetylmorphine (heroin) -- is allowed to cool. Water is added to the mixture at three-times the volume of acetic anhydride, and the mixture is stirred. (Optionally, a small amount of chloroform is added. The mixture is allowed to stand for 20 minutes. The chloroform dissolves colored impurities and settles to the bottom of the pot as a red, greasy liquid, and the water layer is carefully poured off.) Activated charcoal is added to the mixture, absorbing solid impurities, which are filtered out repeatedly until the solution is clear. Approximately 2.2 kilograms of sodium carbonate (soda ash) per kilogram of morphine are dissolved in hot water and added solwly to the mixture until effervescence stops, precipitating solid heroin base. Heroin base is filtered with a fine cloth, set aside and heated until dry. The heroin base should be a granular, white powder at this point. If still colored (beige or light brown), the base may be re-dissolved in dilute hydrochloric or citric acid (8), treated with charcoal again, re-precipitated and dried. Alternatively, in some manufacturing regions, the incompletely purified base may be packed and transported for sale (a practice probably typical in Southwest Asia). About 700 grams of heroin base will be produced from each kilogram of morphine.

Optionally, skilled heroin chemists may further purify the base by dissolving it in twice its mass of boiling ethyl alcohol, filtering the solution through a heated funnel into a heated flask. This removes traces of sodium carbonate remaining in the base. The flask is submerged in an ice bath, where it is transformed into a thick white cream. The substance is placed in a pan in a refrigerator with a fan set to blow across the pan to slowly evaporate the alcohol . The paste crystallizes after several hours and is then vacuum filtered. The product, referred to as alcohol morphine base, is re-crystallized heroin base.

[Hermit]

The fun part, for those presently cowering under the yoke of an oppressive nannystate:

The "nannystate" is a global phenomenon. Clicking on sites the powers that be disapprove of will soon turn you into a "person of interest", and they will have a closer look at what else you're up to. You may not be aware that you have become one until they decide that you have become sufficiently "interesting" to warrant further action. Digital snooping is not confined to tracking your activities for marketing purposes.

[laklak]

I want to make LSD. Pure shit. And some MDMA.

Anybody got a decent recipe?

[piscator]

I want to make LSD. Pure shit. And some MDMA.

Anybody got a decent recipe?

By reacting N-benzoyl-3-(B-carboxyethyl)-dihydroindole (see JCS, 3158 (1931) for the preparation of this compound) with thionyl chloride, followed by aluminum chloride gives 1-benzoyl-5-keto-1,2,2a,3,4,5-hexahydrobenzindole. This is then brominated to give the 4-bromo-derivative, which is converted to the ketol-ketone by reacting with methylamine acetone ethylene ketol. This is then hydrolized by acid to yield the diketone and treated with sodium methoxide to convert it to the tetracyclic ketone. Acetylate and reduce this ketone with sodium borohydride to get the alcohol, which is converted to the hydrochloride form, as usual.
The above hydrochloride is treated with thionyl chloride in liquid sulfur dioxide, to produce an amorphous chloride hydro chloride, which is converted to the nitrile with sodium cyanide in liquid hydrogen cyanide. Methanolysis then gives the ester of the nitrile. Alkaline hydrolysis of this last compound, followed by catalytic dehydrogenation in water using a deactivated Raney Nickle catalyst (see JOC. 13, 455 1948) gives dl-lysergic acid.

[laklak]

Can you give the measurements in cups and tablespoons?

[JimC]

Alcohol is a hard drug.

Withdrawal is more severe than heroin, there are more addicts, and it kills more people.

Simples!

Don't withdraw!

[JimC]

The fun part, for those presently cowering under the yoke of an oppressive nannystate:

The "nannystate" is a global phenomenon. Clicking on sites the powers that be disapprove of will soon turn you into a "person of interest", and they will have a closer look at what else you're up to. You may not be aware that you have become one until they decide that you have become sufficiently "interesting" to warrant further action. Digital snooping is not confined to tracking your activities for marketing purposes.

Luckily, the powers that be don't give a flying continental fuck about Rationalia...