Immune System

Post Reply
User avatar
Tero
Just saying
Posts: 47197
Joined: Sun Jul 04, 2010 9:50 pm
About me: 15-32-25
Location: USA
Contact:

Immune System

Post by Tero » Wed Mar 11, 2020 10:34 am

With these pandemics and viruses popping up in news, I was forced to once more review the immune system. Wikipedia articles have limited examples. Using Google Scholar found this article.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489343/

Invaders have DNA or RNA and protein and do some processing using our enzymes. The pieces are different from ours, so the immune system is set up to recognize broad catergories of viruses. It looks at the DNA and RNA as well as proteins. Some of those proteins are not ours. The cell is set up to do this but the cells can also lyse once a certain point is reached. It is ready to take one for the team.

Image
https://reactome.org/content/detail/R-HSA-168249
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

User avatar
Tero
Just saying
Posts: 47197
Joined: Sun Jul 04, 2010 9:50 pm
About me: 15-32-25
Location: USA
Contact:

Re: Immune System

Post by Tero » Wed Mar 11, 2020 10:46 am

The system is set up very well to recognize things that are "not you." It does not need to know what the invader is other than virus vs other.

https://en.wikipedia.org/wiki/Innate_im ... pecificity

Viruses
Type I interferons (IFN), secreted mainly by dendritic cells,[22] play a central role in antiviral host defense and a cell's antiviral state.[23] Viral components are recognized by different receptors: Toll-like receptors are located in the endosomal membrane and recognize double-stranded RNA (dsRNA), MDA5 and RIG-I receptors are located in the cytoplasm and recognize long dsRNA and phosphate-containing dsRNA respectively.[24] When the cytoplasmic receptors MDA5 and RIG-I recognize a virus the conformation between the caspase-recruitment domain (CARD) and the CARD-containing adaptor MAVS changes. In parallel, when toll-like receptors in the endocytic compartments recognize a virus the activation of the adaptor protein TRIF is induced. Both pathways converge in the recruitment and activation of the IKKε/TBK-1 complex...
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

User avatar
Brian Peacock
Tipping cows since 1946
Posts: 37953
Joined: Thu Mar 05, 2009 11:44 am
About me: Ablate me:
Location: Location: Location:
Contact:

Re: Immune System

Post by Brian Peacock » Wed Mar 11, 2020 11:08 am

And we woulda gotten away with it if it weren't for them pesky RNA recombiners! :lay:
Rationalia relies on voluntary donations. There is no obligation of course, but if you value this place and want to see it continue please consider making a small donation towards the forum's running costs.
Details on how to do that can be found here.

.

"It isn't necessary to imagine the world ending in fire or ice.
There are two other possibilities: one is paperwork, and the other is nostalgia."

Frank Zappa

"This is how humanity ends; bickering over the irrelevant."
Clinton Huxley » 21 Jun 2012 » 14:10:36 GMT
.

User avatar
Tero
Just saying
Posts: 47197
Joined: Sun Jul 04, 2010 9:50 pm
About me: 15-32-25
Location: USA
Contact:

Re: Immune System

Post by Tero » Wed Mar 11, 2020 11:47 am

It gets complicated after the antbodies are recruited. Under adaptive immunity in books is the antibody business. They are mostly markers, with big nasty phagocytes doing the killing.
FAEBC95E-6EBD-4A5D-ADD7-2283F79B692D.jpeg
https://en.wikipedia.org/wiki/Antibody
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

User avatar
NineBerry
Tame Wolf
Posts: 8950
Joined: Thu Feb 26, 2009 1:35 pm
Location: nSk
Contact:

Re: Immune System

Post by NineBerry » Wed Mar 11, 2020 2:41 pm

Image
Image

User avatar
Tero
Just saying
Posts: 47197
Joined: Sun Jul 04, 2010 9:50 pm
About me: 15-32-25
Location: USA
Contact:

Re: Immune System

Post by Tero » Wed Mar 11, 2020 4:13 pm

Lovely phagocytes.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

Post Reply

Who is online

Users browsing this forum: Google [Bot] and 16 guests