Infectious diseases and epidemics

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Tero
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Infectious diseases and epidemics

Post by Tero » Mon Apr 06, 2020 9:20 pm

I put in the inclusive infectious part, as we have not known much about this till after 1850. The book store had a table of disease stuff, some just quickly put out, there was even a 50 page thing called how to deal with coronavirus.

I read most of a book by Steven Johnson, which I will not keep, but was interesting enough. It includes some details about sewers and water works I had not seen in historical context. It's on cholera. My review will not appear under the book for days, maybe not weeks, as I put in a scary word for Amazon review text: internet. If you put an actual web address in your review, they will not publish it.

https://www.amazon.com/dp/1594482691/re ... UTF8&psc=1
The author has read a large amount of Victorian text to produce this document. The story flows well enough, you can skip over some sections, such as the overly thorough history of the "miasma" concept, a false theory now debunked with the two main characters investigating.

Problems: The book is titled after maps produced by John Snow, the first epidemiologist, we learn. Yet, there is not a decent reproduction of the map. You can find it all over the internet, but hey, I paid for a book!

The world wide description of cities and their waste and fresh water supply is well summarized in about 10 pages. By 1885 most of it had been sorted out, with cholera mostly wiped out. There were still epidemics and it took well into the 1900s to figure out how to treat cholera. He does not actually describe the attempts, even in Victorian times, very well. He alludes to IV fluids, which is in fact how you treat it now, if you have a hospital. But other methods are used, see WHO and cholera.

He kind of rambles onto modern day problems with epidemics, including H5N1 influenza. For several pages he talks about bacteria and viruses and DNA. No influenza has DNA, it only has RNA. A cartoon of viral replication would have been more useful. If you are interested in other epidemics, try the Oxford Short Introductions book on the topic.
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Re: Infectious diseases and epidemics

Post by Woodbutcher » Tue Apr 07, 2020 12:55 am

I think Finland had a cholera epidemic in the 1830s. I have seen some examples of cholera mail from that period, they punched holes in the envelopes and blew sulphurous smoke in to kill the bacterium. I'll have to see if I can get one of those envelopes in an auction in the future.
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Re: Infectious diseases and epidemics

Post by Tero » Tue Apr 07, 2020 8:57 pm

AF488532-1239-4CE4-B28C-F83010524FC0.jpeg
Related to coronavirus, small pox carries the patient some 14 days away before they are infected. The virus is DNA so the drugs eventually developed are unlikely to work for coronavirus, an RNA virus.
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Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Re: Infectious diseases and epidemics

Post by Tero » Tue Apr 07, 2020 9:00 pm

EE040F68-CA95-4A8E-869B-62626DAEF7B6.jpeg
Links to those medicines and their targets, which could in fact be targets for any antiviral drug, are in the link. But each virus has its own protein baggage.

https://en.wikipedia.org/wiki/Smallpox
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Re: Infectious diseases and epidemics

Post by Tero » Tue Apr 07, 2020 9:07 pm

Small pox
The virus is acquired from inhalation (breathing into the lungs). Virus particles can remain on such items as clothing, bedding, and surfaces for up to one week.

The virus starts in the lungs. From there, the virus invades the bloodstream and spreads to the skin, intestines, lungs, kidneys, and brain. The virus activity in the skin cells creates a rash that starts as macules (flat, red lesions). After this, vesicles (raised blisters) form. Then, pustules (pus-filled pimples) appear about 12-17 days after a person becomes infected. Survivors of smallpox often have severely deformed skin from the pustules.

https://www.emedicinehealth.com/smallpo ... f_smallpox
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http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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Re: Infectious diseases and epidemics

Post by Tero » Wed Apr 08, 2020 9:09 pm

The drug whose anslog I worked on in the late 80s
A2C83190-20AB-4433-82C0-E00CF3322C16.jpeg
The in vivo therapeutic index was not sufficient for the compound to be further developed as an antiviral drug. The drug was concurrently identified in a screening programme of new anticancer drugs conducted at Lilly Research Laboratories as having a unique mechanism...

The antiviral activity was there, and HIV was a primary target for these agents back then. It was cytotoxic to human cells, so it did not have the required toxic/ therapeutic ratio.
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

User avatar
Tero
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Re: Infectious diseases and epidemics

Post by Tero » Wed Jul 29, 2020 3:33 pm

I've collected a few books on infective agents and the immune system the past few months. The same immune system has to tackle all invaders. It's interesting that you do not usually get long term immunity to bacteria.
https://www.immunology.org/public-infor ... s-bacteria

https://www.eurekaselect.com/87341/arti ... infections

A few vaccines exist
https://en.wikipedia.org/wiki/Pneumococcal_vaccine

HOWEVER, if you get syphilis once, get cured, you do not get immunity. Due to "serotypes."
https://esapolitics.blogspot.com
http://esabirdsne.blogspot.com/
Said Peter...what you're requesting just isn't my bag
Said Daemon, who's sorry too, but y'see we didn't have no choice
And our hands they are many and we'd be of one voice
We've come all the way from Wigan to get up and state
Our case for survival before it's too late

Turn stone to bread, said Daemon Duncetan
Turn stone to bread right away...

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