Calilasseia might have already enlightened you about the importance of this gene and this protein in the determination of cranial capacity (a nonsense mutation causes microcephaly) , I wish to add some details on it's structure... basically, the protein is of an uncharacterized nature, and in these cases one could well try and apply the technology of bioinformatics for de-novo structural prediction, which is what I did using the Swiss-MODEL homology modelling software.
The protein itself has 3477 amino acids, the software was able to predictively model the structure of three unique segments of residue ranges 47-142 , 959-1260 and 2622-2693
with sequence similarities in the 20-30% range to proteins of a similar structure already verified, which served as templates, I recommend you stay tuned for structural eye candy tomorrow
