Anxiety and Depression

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Svartalf
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Re: Anxiety and Depression

Post by Svartalf » Wed Jul 20, 2022 4:52 pm

well, the rat race is a major factor in depression
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Re: Anxiety and Depression

Post by JimC » Wed Jul 20, 2022 9:14 pm

:rimshot:
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Re: Anxiety and Depression

Post by pErvinalia » Thu Jul 21, 2022 6:48 am

https://theconversation.com/depression- ... 1658354452
The serotonin theory of depression has been one of the most influential and extensively researched biological theories of the origins of depression. Our study shows that this view is not supported by scientific evidence. It also calls into question the basis for the use of antidepressants.

Most antidepressants now in use are presumed to act via their effects on serotonin. Some also affect the brain chemical noradrenaline. But experts agree that the evidence for the involvement of noradrenaline in depression is weaker than that for serotonin.

There is no other accepted pharmacological mechanism for how antidepressants might affect depression. If antidepressants exert their effects as placebos, or by numbing emotions, then it is not clear that they do more good than harm.

Although viewing depression as a biological disorder may seem like it would reduce stigma, in fact, research has shown the opposite, and also that people who believe their own depression is due to a chemical imbalance are more pessimistic about their chances of recovery.

It is important that people know that the idea that depression results from a “chemical imbalance” is hypothetical. And we do not understand what temporarily elevating serotonin or other biochemical changes produced by antidepressants do to the brain. We conclude that it is impossible to say that taking SSRI antidepressants is worthwhile, or even completely safe.

....

Although a famous early study found a relationship between the serotonin transporter gene and stressful life events, larger, more comprehensive studies suggest no such relationship exists. Stressful life events in themselves, however, exerted a strong effect on people’s subsequent risk of developing depression.
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Tero
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Re: Anxiety and Depression

Post by Tero » Wed Aug 03, 2022 10:21 am

How do antidepressants work?
In truth, we still don’t really know how or why antidepressants work. The brain is a complex organ. We still don’t have a clear idea about how general anaesthetics work. But few people would refuse an anaesthetic when contemplating serious surgery on this basis.

In the same vein, when contemplating whether an antidepressant might be an option for someone with depression, it is of little consequence that its mechanism of action is incompletely understood.

So let’s put the chemical imbalance theory to bed. We should continue our efforts to understand the nature of depression while we keep searching for better treatments.
https://www.theguardian.com/commentisfr ... -dont-work
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Re: Anxiety and Depression

Post by rainbow » Thu Aug 04, 2022 9:11 am

Tero wrote:
Wed Aug 03, 2022 10:21 am
How do antidepressants work?
In truth, we still don’t really know how or why antidepressants work. The brain is a complex organ. We still don’t have a clear idea about how general anaesthetics work. But few people would refuse an anaesthetic when contemplating serious surgery on this basis.

In the same vein, when contemplating whether an antidepressant might be an option for someone with depression, it is of little consequence that its mechanism of action is incompletely understood.

So let’s put the chemical imbalance theory to bed. We should continue our efforts to understand the nature of depression while we keep searching for better treatments.
https://www.theguardian.com/commentisfr ... -dont-work
Not entirely true.
Some neurotransmitters - serotonin, norepinephrine, dopamine can be measurably low in depressed people. So inhibiting their uptake helps mood.
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